Hope for liver failure patients..
Pig liver successfully passes blood filtering
test outside a man's brain dead body
Pig liver surgeons were linked, externally, to a brain dead human body and watched
as it succeeded in filtering the blood, an important step towards eventually
experimenting with this technique on patients with liver failure.
The University of
Pennsylvania announced the new experiment
as a different experiment on animal-to-human transplants.
In this case
the pig liver was used outside the donor body
not inside
which is a way to create a "bridge" to support the failed liver by doing blood
cleaning work for the organ externally, just like dialysis in case of kidney failure.
Transplants from animal to human
called xenotransplants
have failed for decades because humans' immune systems rejected alien tissues.
Now scientists are trying again with pigs whose organs have been genetically
modified to be more human-like.
In recent years
kidneys from GM pigs have been temporarily transplanted into
brain-deceased donors to see how well they work
and two men have received heart transplants from pigs
despite their deaths within months.
The US Food and Drug Administration is considering whether to
allow a small number of Americans who need a new organ to volunteer
for careful studies either on pigs' hearts or kidneys.
Some researchers also
look forward to using pig liver, although the liver has
different complications from the kidneys and heart, it filters blood
removes waste
and produces materials for other body functions.
In the Pennsylvania experiment, researchers attached a pig liver
a genetically modified liver by the biotechnology company eGenesis
to a device manufactured by the medical device company OrganOx
that helps preserve the human liver donated before the transplant.
The deceased's family, whose body organs were not suitable for donation
awarded the body for scientific research. The organs maintained
blood circulation in the body.
During last month's trial, blood was filtered through a 72-hour pig liver device.
The Pennsylvania team reported in a statement that the donor's
body remained stable and the pig's liver showed no signs of damage.
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